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Fat Loss4 cited studies

SLU-PP-332

Exercise-mimetic ERR agonist studied for mitochondrial energy signaling and metabolic flexibility.

Also known as: SLU PP 332 ยท SLUPP332
SummaryMechanismDosingSafetyStudies
Research use only โ€” not for human consumption.

What it is

SLU-PP-332 is a synthetic small molecule often grouped with peptide-style metabolic compounds. It is studied for exercise-mimetic signaling, endurance, mitochondrial respiration, fatty-acid oxidation, and metabolic-health research.

Mechanism of action

SLU-PP-332 activates estrogen-related receptors ERRalpha, ERRbeta, and ERRgamma, nuclear receptors that regulate oxidative phosphorylation, mitochondrial metabolism, fatty-acid oxidation, and exercise-responsive gene programs.

Evidence summary

Current evidence is preclinical and analytical. Mouse studies report an acute aerobic exercise-like transcriptional response, improved endurance capacity, and metabolic-syndrome improvements. It has no established human clinical dosing.

Typical dosing protocols

Typical dose
250โ€“500 mcg
Frequency
5x per week
Cycle length
8 weeks
  • 5 mg vial reconstituted with 2.0 ml bacteriostatic water
  • 250-500 mcg subcutaneous, 1-2 times daily
  • 5 days on / 2 days off for 4-8 weeks; morning or pre-workout timing is common

Side effects & safety

  • Injection-site redness, tenderness, itching, or mild swelling
  • Headache, nausea, digestive upset, restlessness, or sleep disruption if taken late
  • Use cautiously in athletes because exercise mimetics and metabolic modulators can raise sport-eligibility concerns

Cited studies

  1. Billon C, et al. (2023). Synthetic ERRalpha/beta/gamma agonist induces an acute aerobic exercise response and enhances exercise capacity. ACS Chemical Biology.
    PMID 36988910Read source โ†—
  2. Billon C, et al. (2023). A Synthetic ERR Agonist Alleviates Metabolic Syndrome. ACS Pharmacology & Translational Science.
    PMID 37739806Read source โ†—
  3. (2026). Chemical optimization of the exercise mimetic SLU-PP-332. PubMed.
    PMID 41850449Read source โ†—
  4. (2026). Analysis and identification of in vitro metabolites of SLU-PP-332 for doping-control purposes. PubMed.
    PMID 41688415Read source โ†—
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.