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Pantheon Peptides
Anti-Aging5 cited studies

MOTS-c

Mitochondrial-derived peptide with roles in metabolic homeostasis and exercise response.

Also known as: MOTS c ยท MOTSc
SummaryMechanismDosingSafetyStudies
Research use only โ€” not for human consumption.

What it is

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA. It regulates metabolism, supports cellular energy production, and improves insulin sensitivity. Acting like a metabolic exercise mimetic, MOTS-c reduces metabolic stress, supports mitochondrial health, and may promote healthy aging by reducing inflammation and improving endurance.

Mechanism of action

Activates AMPK, promotes glucose uptake and fatty-acid oxidation, and mimics some effects of exercise. Recent work shows MOTS-c translocates to the nucleus to regulate stress-response gene expression.

Evidence summary

Animal studies demonstrate improved insulin sensitivity, reduced obesity, enhanced endurance, and extended healthspan. Human data is early but promising โ€” circulating MOTS-c declines with age.

Typical dosing protocols

Typical dose
5000โ€“10000 mcg
Frequency
Once weekly
Cycle length
16 weeks
  • 5โ€“10 mg subcutaneous weekly (most common protocol)
  • Some protocols use 10 mg daily for 5 days, then 2ร— weekly
  • 12โ€“16 week cycles

Side effects & safety

  • Transient flushing post-injection
  • Injection-site irritation possible
  • No long-term human safety data

Cited studies

  1. Lee C, Zeng J, Drew BG, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism.
    PMID 25738459Read source โ†—
  2. (2018). The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism.
    Read source โ†—
  3. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications.
    Read source โ†—
  4. (2020). MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. International Journal of Molecular Sciences.
    Read source โ†—
  5. (2022). Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism, and aging. Journal of Translational Medicine.
    Read source โ†—
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.