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Pantheon Peptides
Anti-Aging5 cited studies

Epithalon

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and circadian restoration.

Also known as: Epitalon
SummaryMechanismDosingSafetyStudies
Research use only โ€” not for human consumption.

What it is

Epithalon (also spelled Epitalon) is a synthetic version of the natural pineal tetrapeptide epithalamin. It is best known for stimulating telomerase activity and has been studied for telomere maintenance, immune function, antioxidant defense, and pineal-mediated melatonin and sleep-cycle restoration in aging populations.

Mechanism of action

Proposed to activate telomerase expression, lengthening telomeres in somatic cells. Modulates pineal gland output and AEDG-driven gene expression linked to neurogenesis and circadian regulation.

Evidence summary

Russian longevity research over 10+ years has reported reduced mortality and tumor incidence in elderly cohorts and animal models. Western replication is limited โ€” evidence is suggestive but not yet definitive.

Typical dosing protocols

Typical dose
5000โ€“10000 mcg
Frequency
Once daily
Cycle length
2 weeks
  • 5โ€“10 mg subcutaneous daily for 10โ€“20 consecutive days
  • Repeat 1โ€“2 times per year (long break between courses)
  • Best timed in evening to support circadian effects

Side effects & safety

  • No serious adverse effects reported in published trials
  • Possible mild fatigue during first few days
  • Long-term Western safety data is limited

Cited studies

  1. Khavinson VKh, Bondarev IE, Butyugov AA (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine.
    PMID 14523518Read source โ†—
  2. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules (NLM).
    Read source โ†—
  3. (2003). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology (NLM).
    Read source โ†—
  4. (2006). Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. Bulletin of Experimental Biology and Medicine.
    Read source โ†—
  5. Anisimov VN, Khavinson VKh, Provinciali M, et al. (2002). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer.
    PMID 11857391Read source โ†—
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.