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Pantheon Peptides
Immunity6 cited studies

Thymulin

Zinc-bound thymic nonapeptide — T-cell maturation and anti-inflammatory immune modulation.

Also known as: FTS
SummaryMechanismDosingSafetyStudies
Research use only — not for human consumption.

What it is

Thymulin (FTS-Zn) is a zinc-binding nonapeptide produced by thymic epithelial cells. It supports T-cell differentiation and effective immune responses, with anti-inflammatory and immunomodulatory effects relevant to autoimmunity, allergic disease, and pain modulation.

Mechanism of action

Biological activity requires zinc — the Zn2+ form binds T-cell membrane receptors and modulates T-cell maturation, NK activity, and cytokine balance. Animal models support roles in restraining Th17-driven autoimmune inflammation.

Half-life: Short — typical thymic peptide kinetics; therapeutic regimens deliver repeated doses.

Evidence summary

Earlier clinical data in rheumatoid arthritis (1984, 1987) showed clinical and immune improvements. Modern preclinical work demonstrates benefit in allergic asthma, experimental autoimmune encephalomyelitis, and inflammatory pain pathways via spinal signalling.

Typical dosing protocols

Typical dose
100–500 mcg
Frequency
2x per week
Cycle length
8 weeks
  • 100–500 mcg subcutaneous, 2–3× weekly
  • 8-week cycles for immune modulation research
  • Co-supplementation with zinc commonly cited

Side effects & safety

  • Generally well-tolerated in published trials
  • Mild injection-site reactions
  • Long-term human safety data is limited

Cited studies

  1. (1984). Thymuline (FTS) in rheumatoid arthritis. Arthritis and Rheumatism.
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  2. (1987). An open trial of thymulin (FTS-Zn) in rheumatoid arthritis patients: sequential clinical and immunological follow-up. Clinical and Experimental Rheumatology.
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  3. (2013). Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis. Immunobiology.
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  4. (2019). Protective Effect of PBCA Nanoparticles Loaded with Thymulin Against the Relapsing-Remitting Form of Experimental Autoimmune Encephalomyelitis in Mice. International Journal of Molecular Sciences (MDPI).
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  5. (2019). Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways. International Immunopharmacology.
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  6. (2020). Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma. Science Advances.
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Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.