What it is
KPV (Lys-Pro-Val) is the C-terminal tripeptide sequence of alpha-MSH. Pantheon's source article frames it as a gut, skin, and immune-balance research peptide for inflammatory signaling, intestinal barrier support, and tissue-repair contexts.
Mechanism of action
KPV is transported into epithelial and immune cells through peptide transporters such as PepT1, where it has been shown in models to reduce NF-kB and MAPK inflammatory signaling and lower downstream cytokine activity such as IL-8.
Evidence summary
Evidence is strongest in cell and animal models of intestinal inflammation, barrier function, and antimicrobial activity. Human dosing data remains limited, so protocols should be conservative and educational.
Pantheon dosing guide
- Application
- Subcutaneous injection.
- BAC Water
- 2 ml
- Dose
- 250-500 mcg (5-10 units)
- Frequency & Cycle Length
- 5 days on / 2 days off. 4 to 8 weeks.
- Timing
- Patient Preference. Morning most common. Take at the same time each day.
- Key Benefits
- Supports healthy inflammatory response. Supports gut lining and intestinal barrier health. Supports immune balance. Supports skin and tissue repair.
Additional research protocol context
The printed guide above is Pantheon's dosing reference. These broader research examples are provided as context and may use different schedules.
- 10 mg vial reconstituted with 2.0 ml bacteriostatic water
- 250-500 mcg subcutaneous, 5 days on / 2 days off
- 4-8 week cycle; morning or same time daily is most common
Side effects & safety
- Injection-site redness, tenderness, itching, or mild swelling
- Headache, nausea, lightheadedness, fatigue, or temporary digestive changes
- Rare sensitivity or allergic-type reactions; discontinue and seek guidance if concerning symptoms occur
Cited studies
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT, et al. (2008). PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation. Gastroenterology.Read source ↗
- Xiao B, Laroui H, Ayyadurai S, et al. (2017). Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular Therapy.PMID 28143741Read source ↗
- Cutuli M, Cristiani S, Lipton JM, Catania A (2000). Antimicrobial effects of alpha-MSH peptides. Journal of Leukocyte Biology.PMID 10670585Read source ↗
- Brzoska T, Luger TA, Maaser C, Abels C, Bohm M (2008). alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of the Rheumatic Diseases.Read source ↗
All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.