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Pantheon Peptides
Gut Health4 cited studies

KPV

Alpha-MSH-derived tripeptide studied for gut-barrier integrity, inflammation balance, and tissue support.

Also known as: Lys-Pro-Val
SummaryMechanismDosingSafetyStudies
Research use only โ€” not for human consumption.

What it is

KPV (Lys-Pro-Val) is the C-terminal tripeptide sequence of alpha-MSH. Pantheon's source article frames it as a gut, skin, and immune-balance research peptide for inflammatory signaling, intestinal barrier support, and tissue-repair contexts.

Mechanism of action

KPV is transported into epithelial and immune cells through peptide transporters such as PepT1, where it has been shown in models to reduce NF-kB and MAPK inflammatory signaling and lower downstream cytokine activity such as IL-8.

Evidence summary

Evidence is strongest in cell and animal models of intestinal inflammation, barrier function, and antimicrobial activity. Human dosing data remains limited, so protocols should be conservative and educational.

Typical dosing protocols

Typical dose
250โ€“500 mcg
Frequency
5x per week
Cycle length
8 weeks
  • 10 mg vial reconstituted with 2.0 ml bacteriostatic water
  • 250-500 mcg subcutaneous, 5 days on / 2 days off
  • 4-8 week cycle; morning or same time daily is most common

Side effects & safety

  • Injection-site redness, tenderness, itching, or mild swelling
  • Headache, nausea, lightheadedness, fatigue, or temporary digestive changes
  • Rare sensitivity or allergic-type reactions; discontinue and seek guidance if concerning symptoms occur

Cited studies

  1. Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT, et al. (2008). PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation. Gastroenterology.
    Read source โ†—
  2. Xiao B, Laroui H, Ayyadurai S, et al. (2017). Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular Therapy.
    PMID 28143741Read source โ†—
  3. Cutuli M, Cristiani S, Lipton JM, Catania A (2000). Antimicrobial effects of alpha-MSH peptides. Journal of Leukocyte Biology.
    PMID 10670585Read source โ†—
  4. Brzoska T, Luger TA, Maaser C, Abels C, Bohm M (2008). alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of the Rheumatic Diseases.
    Read source โ†—
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.