What it is
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during EEG delta-sleep states. It is investigated for support of healthy sleep patterns, calming of the nervous system, deeper rest, and stress-response and recovery during physical and mental strain.
Mechanism of action
Modulates GABAergic and opioidergic systems, influences hypothalamic-pituitary-adrenal axis output, and may shift EEG architecture toward slow-wave (delta) sleep. Exact receptor targets remain incompletely characterised.
Half-life: Short — minutes to ~30 minutes in plasma.
Evidence summary
Original 1981 clinical work showed improvements in disturbed sleep. Modern reviews summarise its broader stress-modulation profile. Robust large-scale RCTs are limited.
Pantheon dosing guide
- Application
- Subcutaneous injection.
- BAC Water
- 2.5 mL
- Dose
- 5 units (100 mcg) to 15 units (300 mcg).
- Frequency & Cycle Length
- 5 to 7 days a week. 4 to 8 weeks on, then 2 to 4 weeks off.
- Timing
- Take at approximately the same time each night for more consistent results
- Key Benefits
- Promotes deeper restorative sleep Easing the transition into sleep. Fewer wake-ups. Indirectly supports mood and focus.
Additional research protocol context
The printed guide above is Pantheon's dosing reference. These broader research examples are provided as context and may use different schedules.
- 100–500 mcg subcutaneous, ~30–60 minutes pre-bed
- 4-week cycles common
- Often combined with magnesium / sleep-hygiene routine
Side effects
- Generally well-tolerated; mild dizziness or headache possible
- Vivid dreams reported anecdotally
- Long-term human safety data is limited
Cited studies
- (1981). The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia (NLM).Read source ↗
- (2019). Delta sleep-inducing peptide. Reference Module in Biomedical Sciences (ScienceDirect).Read source ↗
- (2025). DSIP Peptide: Benefits, Dosage, Side Effects & Clinical Data. Exploring Peptides (clinical review).Read source ↗
Content is provided for research and educational purposes only. Products are intended solely for laboratory research and are not for human use. Nothing on this page constitutes medical advice.