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Libido3 cited studies

Kisspeptin-10

Hypothalamic peptide that drives GnRH release — central regulator of reproductive endocrinology.

Also known as: Kisspeptin 10
SummaryMechanismDosingSafetyStudies
Research use only — not for human consumption.

What it is

Kisspeptin-10 is a peptide that stimulates the release of gonadotropin-releasing hormone (GnRH), in turn driving LH and FSH and downstream sex-steroid production. Research interest spans fertility, libido, sexual function, pubertal disorders, and emerging mood / hormonal-balance applications.

Mechanism of action

Activates KISS1R (formerly GPR54) on hypothalamic GnRH neurons, generating pulsatile GnRH release upstream of the entire HPG axis. Kisspeptin neurons in the arcuate nucleus are the canonical 'master switch' of mammalian reproduction.

Half-life: Short — minutes; pulsatile or repeat dosing typically used in research.

Evidence summary

First-in-human work (Dhillo, JCEM 2011) showed reliable LH stimulation. Subsequent intranasal and metabolic / endocrine studies (Lancet eBioMed 2025; preclinical 2025) extend the mechanism to non-reproductive endpoints.

Typical dosing protocols

Typical dose
200–500 mcg
Frequency
3x per week
Cycle length
4 weeks
  • 200–500 mcg subcutaneous, 2–3× weekly
  • 4-week cycles for libido / HPG support
  • Pre-cycle baseline labs (LH, FSH, testosterone, estradiol) recommended

Side effects & safety

  • Generally well-tolerated in clinical research
  • Transient flushing or mild headache
  • Long-term human safety data is limited
Contraindications
  • • Active hormone-sensitive malignancy
  • • Pregnancy

Cited studies

  1. (2011). First-in-human kisspeptin-10 study showing LH stimulation. Journal of Clinical Endocrinology & Metabolism.
    Read source ↗
  2. (2025). Intranasal kisspeptin clinical study (reproductive hormone profiles). The Lancet eBioMedicine.
    Read source ↗
  3. (2025). Kisspeptin-10 metabolic/endocrine effects in a preclinical model. Biomolecules (MDPI).
    Read source ↗
Disclaimer

All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.