What it is
Kisspeptin-10 is a peptide that stimulates the release of gonadotropin-releasing hormone (GnRH), in turn driving LH and FSH and downstream sex-steroid production. Research interest spans fertility, libido, sexual function, pubertal disorders, and emerging mood / hormonal-balance applications.
Mechanism of action
Activates KISS1R (formerly GPR54) on hypothalamic GnRH neurons, generating pulsatile GnRH release upstream of the entire HPG axis. Kisspeptin neurons in the arcuate nucleus are the canonical 'master switch' of mammalian reproduction.
Half-life: Short — minutes; pulsatile or repeat dosing typically used in research.
Evidence summary
First-in-human work (Dhillo, JCEM 2011) showed reliable LH stimulation. Subsequent intranasal and metabolic / endocrine studies (Lancet eBioMed 2025; preclinical 2025) extend the mechanism to non-reproductive endpoints.
Pantheon dosing guide
- Application
- Subcutaneous injection.
- BAC Water
- 5 mg: 2 ml 10 mg: 2 ml
- Dose
- 5 mg: 10 units (250 mcg). 10 mg: 5 units (250 mcg).
- Frequency & Cycle Length
- Monday, Wednesday and Friday. 6.5 weeks.
- Timing
- Take in the morning on an empty stomach, at least 30 minutes before eating.
- Key Benefits
- Supports fertility by boosting GnRH release. Stimulates and balances sex hormones. Increases testosterone in men. Promotes ovulation and estrogen production in women.
Additional research protocol context
The printed guide above is Pantheon's dosing reference. These broader research examples are provided as context and may use different schedules.
- 200–500 mcg subcutaneous, 2–3× weekly
- 4-week cycles for libido / HPG support
- Pre-cycle baseline labs (LH, FSH, testosterone, estradiol) recommended
Side effects & safety
- Generally well-tolerated in clinical research
- Transient flushing or mild headache
- Long-term human safety data is limited
- • Active hormone-sensitive malignancy
- • Pregnancy
Cited studies
- (2011). First-in-human kisspeptin-10 study showing LH stimulation. Journal of Clinical Endocrinology & Metabolism.Read source ↗
- (2025). Intranasal kisspeptin clinical study (reproductive hormone profiles). The Lancet eBioMedicine.Read source ↗
- (2025). Kisspeptin-10 metabolic/endocrine effects in a preclinical model. Biomolecules (MDPI).Read source ↗
All content is for research and educational purposes. Peptides described are sold for laboratory research use only and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any protocol.