SLU-PP-332 · Pantheon Help Center

Primary Benefits

Activates ERR pathways involved in exercise-responsive gene signaling
Supports mitochondrial energy signaling and cellular respiration
Enhances metabolic flexibility and fatty-acid oxidation in preclinical models
Supports endurance and exercise-capacity research
Commonly used for performance, fat metabolism, and metabolic-health research

Mechanism of Action

SLU-PP-332 is a synthetic pan-agonist of estrogen-related receptors (ERRα, ERRβ, and ERRγ), a family of nuclear receptors that regulate genes involved in mitochondrial metabolism, oxidative phosphorylation, fatty-acid oxidation, and exercise adaptation. In cell and animal studies, SLU-PP-332 activates an aerobic exercise-like transcriptional program, increases mitochondrial function and cellular respiration, shifts skeletal muscle toward more oxidative fibers, and improves endurance capacity in mice. It is not technically a peptide, but it is commonly discussed alongside peptide-style performance and metabolic research compounds.

Dosing & Protocol

Subcutaneous (SQ) Injection (preferred)

Reconstitution:

-5 mg vial → 2.0 ml bacteriostatic water

Daily Dose:

-250–500 mcg (10–20 units)

Cycle:

-1–2 times daily, 5 days on / 2 days off; 4–8 weeks or as directed by your healthcare provider

Timing:

-Morning or pre-workout. Fasted state most common

Potential Side Effects

Injection-site redness, tenderness, itching, or mild swelling
Headache, nausea, digestive upset, or changes in appetite
Temporary restlessness, jitteriness, or sleep disruption if taken too late in the day
Increased heart rate, warmth, or exercise intolerance in sensitive individuals (theoretical)
Rare: unusual chest symptoms, severe anxiety, or allergic reaction; discontinue and seek medical guidance

If side effects occur, users commonly reduce dose or discontinue use and consult a healthcare professional.

Common Stacks

With SS-31: For combined mitochondrial structure and exercise-signaling support
With MOTS-C: For metabolic flexibility, AMPK-related signaling, and endurance research
With AOD9604 / 5-Amino-1MQ: For body-composition and fat-metabolism protocols
With NAD+ / L-Glutathione: For cellular energy and oxidative-stress support

Notes

SLU-PP-332 is a research compound with no established human clinical dosing or long-term safety profile.
It is an exercise-mimetic small molecule, not a traditional peptide, even though it is often grouped with peptide products.
Competitive athletes should be cautious because exercise mimetics and metabolic modulators can raise sport-eligibility concerns.
Lyophilized (dry) SLU-PP-332 vials should be stored in the freezer.
After reconstitution, store in the refrigerator and use within 45 days unless the product label or protocol says otherwise.
Use earlier in the day when assessing tolerance, especially in individuals sensitive to stimulation or sleep disruption.

References

Synthetic ERRα/β/γ agonist induces an acute aerobic exercise response and enhances exercise capacity (Billon et al., 2023, ACS Chemical Biology)

Link: https://pubmed.ncbi.nlm.nih.gov/36988910/

A Synthetic ERR Agonist Alleviates Metabolic Syndrome (Billon et al., 2023, ACS Pharmacology & Translational Science)

Link: https://pubmed.ncbi.nlm.nih.gov/37739806/

Chemical optimization of the exercise mimetic SLU-PP-332 (2026, PubMed)

Link: https://pubmed.ncbi.nlm.nih.gov/41850449/

Analysis and identification of in vitro metabolites of SLU-PP-332 for doping-control purposes (2026, PubMed)

Link: https://pubmed.ncbi.nlm.nih.gov/41688415/

Disclaimer

The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.