MOTS-c
Updated April 28, 2026
Primary Benefits:
- Enhances mitochondrial energy production
- Improves physical endurance and exercise capacity
- Supports fat loss and metabolic flexibility
- Promotes healthy aging and cellular stress resistance
Mechanism of Action:
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide encoded in the mitochondrial genome. It regulates metabolic homeostasis by activating AMPK (AMP-activated protein kinase), a master energy sensor in the body. This leads to improved glucose utilization, fat oxidation, and resilience against metabolic stressors—making MOTS-C a unique tool for mitochondrial health and performance optimization.
Dosing & Protocol
Subcutaneous (SQ) Injection:
- Reconstitution:
10 mg vial → 1.0 ml bacteriostatic water - Weekly Dose:
1.5mg (15 units) to 5 mg (50 units) - Cycle:
Once weekly for 2–4 weeks (can repeat as needed) - Timing:
Take on an empty stomach, ideally in the morning or before exercise.
Potential Side Effects:
- Mild injection site irritation or redness
- Transient fatigue or mild headache (rare)
- No known long-term adverse effects in current literature
Common Stacks:
- With 5-Amino-1MQ: For enhanced metabolic activation and fat burning
- With AOD-9604: For synergistic support in body recomposition and weight loss
- With CJC-1295 / Ipamorelin: For enhanced GH-driven fat loss and recovery
Notes:
- Start on the low end of the dosing scale (1.5-2mg) and build each week to get to your desired weekly dose.
- Inject subcutaneously into the abdomen or outer thigh using a sterile insulin syringe.
- MOTS-C is ideal for use in cycles targeting energy enhancement, fat metabolism, or anti-aging.
- For best results, align dosing with physical training or fasting periods.
- Store reconstituted solution in the refrigerator and use within 45 days.
Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.