GHK-Cu
Updated April 28, 2026
Primary Benefits:
- Promotes wound healing and tissue regeneration
- Enhances skin elasticity, firmness, and hydration
- Supports hair growth and scalp health
- Improves collagen synthesis and skin remodeling
- Reduces inflammation and oxidative stress
- May support cognitive and organ repair in systemic use
Mechanism of Action:
GHK-Cu (glycyl-L-histidyl-L-lysine–copper complex) is a naturally occurring copper peptide found in human plasma and saliva. It binds copper ions and facilitates cellular remodeling, collagen production, angiogenesis, and tissue repair. It has high affinity for binding copper(II), and through this interaction, it exerts antioxidant, anti-inflammatory, and regenerative properties.
Dosing & Protocol
Subcutaneous (SQ) or Intramuscular (IM) Injection:
- Reconstitution:
– 50 mg vial → 3.0 ml bacteriostatic water
– 100 mg vial → 3.0 ml bacteriostatic water - Daily Dose:
– 50 mg vial → 835mcg - 1,666mcg (5 - 10 units)
– 100 mg vial → 835mcg - 1,666mcg (2.5 - 5 units)
- Cycle:
5–7 days per week
6–12 weeks on, then 2–4 weeks off - Timing:
Based on personal preference; no strict time requirement
Potential Side Effects:
- Mild irritation or itching at injection site
- Temporary skin discoloration or flushing
- Rare allergic reaction or copper sensitivity
- Avoid use with excessive copper supplementation
Common Stacks:
- With BPC-157 or TB-500: For deep tissue regeneration and post-surgery recovery
- With Epithalon: For anti-aging synergy
- With topical GHK-Cu serums: For external and internal skin rejuvenation support
Notes:
GHK-Cu can be used both topically and systemically. Injectable use may enhance systemic healing benefits including organ repair, hair regrowth, and inflammatory modulation. Store reconstituted solution in the refrigerator and use within 45 days unless the product label or protocol says otherwise.
Zinc Supplement Recommendation:
It is recommended to take zinc with GHK-Cu to support proper copper absorption, prevent buildup, and reduce possible redness or soreness at the injection site. Ensure the zinc supplement does not contain copper.
Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.